Guisen Zhao and Xiaobing Wang Pages 1461 - 1471 ( 11 )
Glutathione-S-transferases (GSTs; EC 2.5.1.18), a family of phase II detoxification enzymes, catalyze the conjugation of glutathione with broad substrates including chemotherapeutic agents, and are involved in cell protection against apoptotic signals by inhibiting the stress-signaling cascade mediated by ASK1 (Apoptosis signal-regulating kinase)-JNK (c-Jun N-terminal kinase). As GSTs are overexpressed in some malignant tumors, GSTs is a promising therapeutic target. This article reviews the progress in the development of GSTs inhibitors and GSTs activated prodrugs.
Glutathione-S-transferases,Antitumor agents,Drug-resistance,GST inhibitors,Prodrugs,Apoptosis
, Department of MedicinalChemistry, College of Pharmacy, Shandong University, Jinan, Shandong250012, PR China.