Adrienne Adams Pages 1667 - 1675 ( 9 )
Acridines have been used as chemotherapeutic agents against bacteria, protozoa and fungi, and they now find important use as anticancer drugs. There is a paucity of crystal structures of acridine-DNA complexes above the dinucleotide level, but recent structures of acridinecarboxamide topoisomerase II poisons complexed to hexanucleotides have allowed a molecular rationalization of their structure-activity relationships for cytotoxicity and for their kinetics of DNA binding.
acridines,crystal structures,nucleic acids,DNA,complexes,acridine-4-carboxamides
School of Molecular andMicrobial Biosciences, University of Sydney, NSW 2006, Australia