Su Tsann-Long Pages 1677 - 1688 ( 12 )
A series of potential topoisomerase II-mediated anticancer 9-anilinoacridine derivatives, which are designed to avoid bio-oxidation and possessed long duration of drug action, is reviewed. Among these agents, 3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives and their alkylcarbamates have been investigated and developed for potential clinical application.
topoisomerase II,anticancer agents,bio-oxidation,potential clinical application,antitumor acridines,human leukemic ccrfcem cells,computer modelling,sar studies,supercoiled dna
Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei 115,Taiwan