Michail Pargianas, Styliani Salta, Katerina Apostolopoulou, Leandros Lazaros , Maria Kyrgiou, Andrea Tinelli, Antonio Malvasi, Ioannis Kalogiannidis, Ioannis Georgiou and Ioannis P. Kosmas* Pages 2087 - 2095 ( 9 )
Premature ovarian failure (POF), which may be undetectable for a long time, is associated with impaired fertility. The mechanisms involved in the pathogenesis of POF as well as the concomitant treatments are still unclear. Although many data exist, mainly produced by the study of transgenic animals under various experimental conditions, they remain fragmented. A systematic review of the pathways involved in premature ovarian failure was conducted. Data extraction was performed from experimental studies until 2019. The molecular processes and their correlation with the follicular developmental stage have been described. Furthermore, the effects in other cells, such as oocytes, granulosa and theca cells have been reported. An overall estimation was conducted.
Fertility, folliculogenesis, ovary, POF, transgenic, follicular.
Department of Obstetrics and Gynecology, Ioannina State General Hospital G. Chatzikosta, Ioannina, University Hospitals of Leicester, Haemophilia Centre, Leicester Royal Infirmary, Leicester, Department of Biological Applications and Technologies, Ioannina University, Ioannina, Genetics and IVF Unit, Department of Obstetrics and Gynecology, Medical School, Ioannina University, Ioannina, West London Gynecological Cancer Center, Queen Charlotte's and Chelsea-Hammersmith Hospital, Imperial Healthcare NHS Trust, London, Moscow Institute of Physics and Technology (State University), Moscow Region, Moscow Institute of Physics and Technology (State University), Moscow Region, Third Department of Obstetrics and Gynaecology, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Genetics and IVF Unit, Department of Obstetrics and Gynecology, Medical School, Ioannina University, Ioannina, Moscow Institute of Physics and Technology (State University), Moscow Region