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Histone Deacetylase Inhibitors: An Attractive Strategy for Cancer Therapy

[ Vol. 20 , Issue. 14 ]


Jiyang Li, Guangqiang Li and Wenqing Xu   Pages 1858 - 1886 ( 29 )


Histone deacetylases are able to catalyze the hydrolysis of N-acetyl lysine residues of histones which package chromosomal DNA. Therefore they play an important role in mediating gene expression and cell proliferation. HDAC inhibitors have not only shown promise as antiparasitic, antineurodegenerative, antirheumatologic agents and immunosuppressant, but as potent anticancer agents by inducing cell cycle arrest, differentiation and apoptosis. This review highlights recent development in design, synthesis and biological evaluation of HDAC inhibitors for cancer therapy.


Antitumor drugs, cancer therapy, cyclic peptide, drug discovery, epigenetic regulation, histone deacetylase, hdac isoforms, histone deacetylase inhibitors, hybrid compounds, multi-targeted inhibitor.


Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Baidi Road 238, Nankai, Tianjin, PRC.

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