Perspective

Oteseconazole: First Approved Orally Bioavailable and Selective CYP51 Inhibitor for the Treatment of Patients with Recurrent Vulvovaginal Candidiasis

Author(s):

Surya K. De*   Pages 4170 - 4175 ( 6 )

Abstract:

Oteseconazole was approved by the US FDA in April 2022. It is the first approved selective and orally bioavailable CYP51 inhibitor for the treatment of patients with recurrent Vulvovaginal candidiasis. Herein, we describe its dosage, administration, chemical structure, physical properties, synthesis, mechanism of action, and pharmacokinetics.

Keywords:

Antifungals, mechanism of action, fungal lanosterol demethylase, vaginitis, sterol biosynthesis, oteseconazole.

Affiliation:

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