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Porous Inorganic and Hybrid Systems for Drug Delivery: Future Promise in Combatting Drug Resistance and Translation to Botanical Applications

[ Vol. 26 , Issue. 33 ]

Author(s):

Junling Guo, Bruno D. Mattos, Blaise L. Tardy, Vanessa M. Moody, Gao Xiao, Hirotaka Ejima, Jiwei Cui*, Kang Liang* and Joseph J. Richardson*   Pages 6107 - 6131 ( 25 )

Abstract:


Background: Porous micro- and nanoparticles have the capacity to encapsulate a large quantity of therapeutics, making them promising delivery vehicles for a variety of applications. This review aims to highlight the latest development of inorganic and hybrid (inorganic/ organic) particles for drug delivery with an additional emphasis on combatting drug resistant cancer. We go one step further and discuss delivery applications beyond medicinal delivery, as there is generally a translation from medicinal delivery to botanic delivery after a short lag time.

Methods: We undertook a search of relevant peer-reviewed publications. The quality of the relevant papers was appraised using standard tools. The characteristics of the papers are described herein, and the relevant material and therapeutic properties are discussed.

Results: We discuss 4 classes of porous particles in terms of drug delivery and theranostics. We specifically focus on silica, calcium carbonate, metal-phenolic network, and metalorganic framework particles. Other relevant biomedically relevant applications are discussed and we highlight outstanding therapeutic results in the relevant literature.

Conclusion: The findings of this review confirm the importance of studying and utilizing porous particles for therapeutic delivery. Moreover, we show that the properties of porous particles that make them promising for medicinal drug delivery also make them promising candidates for agro-industrial applications.

Keywords:

Nanomedicine, drug delivery, porous particles, hybrid, botanic delivery, inorganic.

Affiliation:

Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, Shandong University, Jinan, Shandong 250100, Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, P. O. Box 16300, FI-00076, Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, P. O. Box 16300, FI-00076, Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Pennsylvania 19104, Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, 02115, Department of Materials Engineering, the University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, Shandong University, Jinan, Shandong 250100, School of Chemical Engineering, The University of New South Wales, Sydney, New South Wales, Department of Materials Engineering, the University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656



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