Farahnaz Behzad, Erfan Sefidgar , Azam Samadi , Wensen Lin , Iman Pouladi* and Jiang Pi* Pages 1 - 13 ( 13 )
Tuberculosis (TB), induced by Mycobacterium tuberculosis (MTB), is a fatal infectious disease that kills millions of lives worldwide. The emergence of drug-resistant and multidrug-resistant cases is regarded as one of the most challenging threats to TB control due to the low cure rate. Therefore, TB and drug-resistant TB epidemic urge us to explore more effective therapies. The increasing knowledge of nanotechnology has extended the use of some nanomedicines for disease treatment in clinics, which also provide novel possibilities for nano-based medicines for TB treatment. Zinc oxide nanoparticles (ZnO NPs) have gained increasing attention for anti-bacterial uses based on their strong ability to induce reactive oxidative species (ROS) and release bactericidal Zinc ions (Zn2+), which are expected to act as novel strategies for TB and drug-resistant TB treatment. Some plant extracts, always from active herbal medicines, have been widely reported to show attractive anti-bacterial activity for infectious treatment, including TB. Here, we summarize the synthesis of ZnO NPs using plant extracts (green synthesized ZnO NPs), and further discuss their potentials for anti-TB treatments. This is the first review article discussing the anti-TB activity of ZnO NPs produced using plant extracts, which might contribute to the further applications of green synthesized ZnO NPs for anti-TB and drugresistant TB treatment.
Anti-tuberculosis, drug-resistant, Mycobacterium tuberculosis, plant extract, tuberculosis, metal oxide nanoparticles, ZnO nanoparticles.
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Department of Biological Sciences٫ Institute for Advanced Studies in Basic Sciences٫ Zanjan, Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Department of Clinical Immunology, Institute of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, 523808, Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Department of Clinical Immunology, Institute of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, 523808