Caixia Yuan, Yucen Yao, Tao Liu, Ying Jin*, Chunrong Yang*, Xian Jun Loh and Zibiao Li*
Depression is a common mental illness that belongs to the category of emotional disorders that causes serious damage to the health and life of patients, while inflammation is considered to be one of the important factors that causes depression. In this case, it might be important to explore the possible therapeutic approach by using natural compounds exerting an anti-inflammatory and antidepressant effect, which it filed has not been systematically reviewed recently. Hence, this review aims to systematically sort the literature related to the mechanism of exerting an antidepressant effect through anti-inflammatory actions, and to summarize the related natural products in the past 20 years, in terms of a number of inflammatory related pathways (i.e., the protein kinase B (Akt) pathway, monoamine neurotransmitters (5-hydroxytryptamine and norepinephrine) (5-HT and NE), the nod-like receptor protein-3 (NLRP3) inflammasome, proinflammatory cytokines, neurotrophins, or cytokine-signaling pathways), which might provide a useful reference for the potential treatment of depression.
Depression, anti-inflammatory, NLRP3 inflammasome, proinflammatory cytokine, natural compounds.
School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, College Pharmacy, Jiamusi University, 258 Xuefu Street, Jiamusi, Heilongjiang, 154007, College Pharmacy, Harbin University of commerce, 1Xuehai Street, Harbin, Heilongjiang, 150028, Department of Cardiology, The First Affiliated Hospital of Xiamen University, Xiamen, 361003, College Pharmacy, Jiamusi University, 258 Xuefu Street, Jiamusi, Heilongjiang, 154007, China, Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634, Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634