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Boronate-Based Fluorescent Probes as a Prominent Tool for H2O2 Sensing and Recognition

Author(s):

Ling Wang, Xuben Hou, Hao Fang and Xinying Yang*  

Abstract:


Given the crucial association of hydrogen peroxide with a wide-range of human diseases, this compound has currently earned the reputation of being popular biomolecular target. Although various of analytical methods have attracted our attention, fluorescent probes have been used as prominent tools to determine H2O2 to reflect the physiological and pathological conditions of biological systems, As the sensitive responsive portion of these probes, Boronate ester and boronic acid groups are vital reporter as the sensitive responsive part for H2O2 recognition. In this review, we summarized boronate ester/boronic acid group-based fluorescent probes for H2O2 reported from 2012 to 2020 and generally classify the fluorophores into six categories to exhaustively elaborate the design strategy and comprehensive systematic performance. We hope that this review will inspire the exploration of new fluorescent probes based on boronate ester/boronic acid groups for detection of H2O2 and other relevant analytes.

Keywords:

fluorescent probe, boronate ester/boronic acid, hydrogen peroxide

Affiliation:

Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44, West Culture Road, 250012 Jinan, Shandong, Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44, West Culture Road, 250012 Jinan, Shandong, Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44, West Culture Road, 250012 Jinan, Shandong, Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44, West Culture Road, 250012 Jinan, Shandong



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