S. Kim, J.R. Jensen, K. Cisek, K.E. Funk, S. Naphade, K. Schafer and J. Kuret Pages 230 - 234 ( 5 )
Alzheimers disease is diagnosed by postmortem detection of pathological lesions that accumulate in specific brain regions. Although the presence of both β-amyloid plaques and tau-bearing neurofibrillary lesions defines Alzheimers disease, the distribution of neurofibrillary lesions alone correlates strongly with neurodegeneration and cognitive decline. A whole-brain imaging test capable of detecting these lesions in premortem cases could have great potential for staging and differentially diagnosing Alzheimers disease. Here we discuss the challenges in developing a whole-brain imaging approach for detection of this intracellular target.
Alzheimer's disease,frontotemporal lobar degeneration,tau,neurofibrillary tangle,paired helical filaments
, , , , , , Center for Molecular Neurobiology, 1060 Carmack Rd., Columbus, OH 43210, USA.