Shiroh Futaki, Hisaaki Hirose and Ikuhiko Nakase Pages 2863 - 2868 ( 6 )
Intracellular delivery using cell-penetrating peptides (CPPs) has received considerable attention as a promising method for introducing exogenous molecules into cells. The mechanisms that enable efficient internalization of CPPs together with cargo molecules are also of interest. In this review, we describe our current views of membrane translocation of CPPs, especially those rich in arginine, as these peptides represent one of the most frequently employed classes of CPPs.
Cell-penetrating peptide, arginine, macropinocytosis, membrane-associated proteoglycan, direct translocation, membrane potential, counterion, membrane curvature
, , Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.